Dextromethorphan depression reddit. I realize it's not well studied.

Dextromethorphan depression reddit It helps relieve "dry" cough in adults and children by suppressing the cough reflex. Welcome to r/DXM - a community for discussion of the powerful dissociative cough suppressant DXM and other dissociatives are some of the strongest antidepressants in existence. It did work very well. It was a low bar to prove their outcome: superiority to bupropion alone. 藥理分類: 鎮咳劑: 適應症: 鎮咳 (感冒、咽頭炎、支氣管炎、支氣管擴張症等引起之咳嗽)。 藥品外觀: 標記：15 ； 白色圓形錠劑。 Sounds like you have an enzyme deficiency, that’s why you feel 100mg. Priority questions are whether DXM/bupropion is uniquely effective across discrete domains of psychopathology (e. If you want to recommend that pts get the dextromethorphan OTC, they must get the HBr formulation found in Robitussin. Over-the-counter medicines. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , Wellbutrin SR and XL Hello friends. 77K subscribers in the dxm community. In short, I think it helped If you get antidepressant effects from DXM, go to a doctor and seek out a SSRI prescription. Currently being researched by Axsome Therapeutics as AXS-05 for Major Depressive I just wanted to share how much of a totally radical change taking DXM has made in my cognition, depression, and anxiety. You trip for yourself, not for reddit. The maximum safe Dextromethorphan posseses only a minimal degree of the mu-opioid activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors. . [9] Seit 2013 ist Dextromethorphan daher in den I have been taking 60 mg / night before bed every night of mucinex d (extended release 60 mg dxm) - instead of a ketamine nasal spray in between infusions of ketamine for depression and complex ptsd. If you wanna try dxm and ssris I . First of all, I know dxm can be abused. It does not help with my depression at all but I have been taking 100mg for four years purely because the withdrawls are insane and I can’t get yes, but it has 45mg of dxm and 150mg of wellbutrin i believe. Although structurally similar to other narcotics, DXM does not act as a - mu receptor opioid (e. Download the Medication Guide app on iTunes Download the Medication Guide app on the Google Play store. GENERAL INFORMATION # DXM FAQ. well i had a 15 cc which has 45 mg of dextromethorphan and ate two bupropion 150 and it 75K subscribers in the dxm community. Now I know for experiance, friends, doctors and places like here that DXM abuse or withdrawl/come down can cause / worsen depression and anxiety. MẶc dù cấu trúc hoá học không liên quan gì đến morphin nhưng dextromethorphan có hiệu quả nhất trong điều trị ho mạn tính 80K subscribers in the dxm community. Or check it out in the app stores Welcome to r/DXM - a community for discussion of the powerful dissociative cough suppressant - Dextromethorphan! ADMIN MOD anyone else get that post-plat depression . I proceeded to stay up for around 6 hours after I dosed, till in 4 am. Welcome to r/DXM - a community for discussion of the powerful dissociative cough suppressant Yes, reportedly DXM and Ketamine are similar in their method of action. Just to add, while I was doing dex regularly there was next to no positive affects doing it, I hated the taste, it wouldn't let me sleep, I hated the high and come up. Chemistry and Pharmacology: Dextromethorphan (DXM) (d-3-methoxy-N-methyl-morphinan) is the dextro isomer of levomethorphan, a semisynthetic morphine derivative. oft: DXM, auch DMP) ist ein Arzneistoff, der auf das Nervensystem wirkt. Drugs. This is the DXM you probably hear about most on this sub outside of Delsym and R30's. Overall a great trip, music sounded absolutely wonderful. You'll probably just be very tired for a few hours, but talk to a doctor ASAP to be sure. First, as is the case with esketamine, dextromethorphan does have abuse potential [ 25 ] and no studies have evaluated its utility in patients with depression and comorbid substance use disorders, though abuse Hello, I'm a 30 year old male that's been struggling badly with depression, ADHD, and anxiety. I didn’t get much rebound depression, it got me out of the depressive episode and quitting it was pretty easy. First antidepressant (I’ve been through a lot of SSRIs and SNRIs) that felt like one day somebody raised the window shades and let the Does DXM cause depression for anyone? In the short term it seems to help but the effects overall seem to make things worse when you stop feeling it I do workout and actually you're wrong. have significant known side effects when used properly/close to properly or 2. I've taken DXM a handful of times and can say it does make it stronger but not sure how much stronger. Dextromethorphan HBr. It was incredible. Tbh tho I’m not sure dxm is great for bipolar depression as it seems to induce mania pretty easily. com. But I'm trying it for my depression because nothing else works. The prescribed version of Auvelity (dxm/bupropion) has you start at 45mg dxm daily for a couple days to help you get used to the feeling. But of course, not everyone is Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. Much more communicative now, too. Or check it out in the app stores   hi everyone today i'd like to talk about dxm. com Mobile App. Internet Culture (Viral) I've also heard of DXM causing respiratory depression in massive overdose cases but honestly if you're taking enough DXM to cause dangerous respiratory depression it's probably the least of your worries. No, it’s not taken for depression. like thats not a fucking medical dose, holy shit. DXM Bits & Pieces. It felt like a 300-400mg dxm trip. I searched online & saw that dxm works similar to ketamine for depression (which I have been looking onto but is expensive) It also said that there is a med that combines bupropion & dxm (Auvelity) so I was thinking of bringing that med up to my doc to try but since it’s newer, there doesn’t appear to be a generic so unlikely insurance will Also wondering safety when comparing dxm hbr and dxm freebase, I have heard freebase may be safer due to not containing bromine but is also 30% stronger than hbr. 1898588. its just so little dxm and i often see people sayong "been using 200mg daily for a month for depression". Dextromethorphan (Delsym) is an over-the-counter cough suppressant (antitussive). Honestly it’s a blessing, you don’t need to drink a fuck ton of syrup. View community ranking In the Top 5% of largest communities on Reddit [Article] Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials by Amna Majeed et al. 15mg/Tab. self medicating with dxm is a recipe for psychosis and addiction. That may be the case for you but not for me. Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. Please read about DXM-only products. SSRI's work on serotonin whereas ketamine and dxm work on glutamate. It's just the way it's metabolized and how tolerance forms makes DXM a bad candidate for daily use. I've had clinical depression for several years, and have been on a number of antidepressants, but unfortunately none of them produced AD effects anywhere near those of Bupropion affects a metabolizing enzyme which affects DXM's conversion to DXO, and also the way DXM is processed by your body. DXM as a meditation tool is pretty great though. Woah! So many bans in a single thread! Friendly reminder that r/dxm has Zero Tolerance for bigotry, bullying, and harassment. The maximum safe Sebelum mengonsumsi dextromethorphan sirop, kocok botol obat terlebih dahulu. Illicit Wellbutrin -Bupropion , all things related to this antidepressant. Consume the drugs, don't let them consume you. Find patient medical information for Dextromethorphan on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings There are like 30 other antidepressants all with proven efficacy for depression Which dxm does not. Heck, as much as dxm is used for abuse, it would probably help anything work better in combo than by itself. Oddly enough the bupropion is added because it slows down the metabolism of dextromethorphan therefore making it stay in the body longer which it allows it to work its NMDA-binding anti More serious dextromethorphan side effects include serotonin syndrome. I experience these horrible episodes of depression and wanted to know if its normal. I haven't even dosed for about a year. If you're in the US and want to use DXM for depression continuously, there's a phase 3 study: https://www. This is just a thread to summarize your experiences and opinions on using DXM for depression, social anxiety and other mental health issues. Stay away from the Delsym (dxm polistirex). DXM shows you joy, but it may still be a struggle to keep carrying that joy What type of bipolar is it when you're depressed and you only want to try out drugs that relieve your depression so you can get amazing highs so that you can feel manic nonstop because that particular type of happy mania helps the person be nicer towards other people by becoming a better person who wants to help change the fate of the entire world to make this place a better Get the Reddit app Scan this QR code to download the app now. Dextromethorphan is the primary active ingredient in NyQuil, though 60 mg would be effectively double the normal dose, for the liquid form. Daily use of any substance especially psychoactive is connected to big health risks and dangerous withdrawal. It is in the same class of drugs as ketamine, and has similar neurological effects. I saw they used 45mg of dextromethorphan and 150g of Dextromethorphan Hydrobromide 15 mg (778) View larger images. Or check it out in the app stores     TOPICS. when they have an unknown My psych also suggested Auvelity for depression/anxiety a month ago. obviously at some point it consumes me and im out cold, but i had some pretty DXM has high sigma affinity and DXM's metabolite, DXO, has high NMDA affinity. This activity will highlight the mechanism of Get the Reddit app Scan this QR code to download the app now. trdstudy. If you don't have anything pleasant or nice to say - keep your judgemental opinions to yourself. Dextromethorphan posseses only a minimal degree of the mu-opioid activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors. when they have an unknown According to the company conducting the study, when subjects were given 150mg BUP + 60mg DXM, DXM AUC was 60 times that of 60mg DXM alone, and Cmax was 42 times greater. It can't relieve depression permanently, though what you learn from it can help you feel better in a lasting way. From novel/alternative substances, to established medications. The combination of DXM and bupropion is a safe, well tolerated and efficacious treatment option in adults with MDD. DXM and Drug Tests. (Edit: I was typing Also no alcohol, benzos, opioids, barbiturates or gabapentinoids, this are CNS Depressants and with dxm they can cause severe respiratory depression. Everyone has different brain chemistry. The only reason this has gone forward so quickly is because, 1. Posted by u/qubanlynx - 1 vote and 1 comment So, until 4 days ago, I would take 450mg of bupropion xl every morning. It seems like the sigma-1 receptor activity of DXM is responsible for most of the antidepressant effect. So I looked it up, and apparently it makes the dxm even stronger, and there's even an experimental drug that combines the two for depression. I do alot to battle depression. g. If stop for multiple days the pain comes back stronger, and if I go hard (recreational doses) for weeks to months daily I'll get brain zaps similar to SSRI Dextromethorphan in treatment resistant depression. In 2010, the FDA approved the use of dextromethorphan for pseudobulbar affect in combination with quinidine. I can now take 30 pills without reaching the second plat and have to take 40 to reach the second/third plat. Dxm has been over the counter for 70 years, so i think if it was physically or neurologically dangerous in the type of doses of dxm hbr being used in the medical field ( nuedexta is 45mg dxm hbr/day + quinidine, anf the newly filed patent for depression is how much. But dxm is the thing that does me best. Make sure you have the right intentions and once dxm has given you the help you need don’t use it as a crutch. Posted by u/andrew_fell_asleep - 7 votes and 17 comments Get the Reddit app Scan this QR code to download the app now. It contains the same active ingredient as the brand Get the Reddit app Scan this QR code to download the app now. Applies to dextromethorphan: compounding powder, oral capsule, oral disintegrating strip, oral drops, oral liquid, oral lozenge, oral solution, oral suspension extended release, oral syrup, oral tablet chewable. A ton of people on this sub here sing its praises as a cure for depression, but all it does is mask it. Don't take it from me or anybody on this subreddit, there is loads of literature out there to back this up, both anecdotal and professional. However normal medical doses (I'm talking 15mg - 30mg) of DXM only items seems to cause me massive depression after it wares off for days up to a week. Dextromethorphan comes alone and in combination with antihistamines, cough suppressants, and decongestants. Even a little more is probably fine as well because with an inhibitor you're raising the blood level of dxm so it builds up in your body more than just taking 90mg of pure dxm alone. Expert Opinion on Emerging Drugs, 26(1), 63–74. Buy from robocough. DXM and its This is no recommendation. I would take them twice to three times a day, doses of 8-30 pills at once. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product It doesn't work as one would suspect as the ingredient that is actually treating depression is the dextromethorphan and not bupropion as one would assume. It also comes as an immediate-release (IR) caplet that's In that aspect, DXM has lots of potential, But there's better drugs out there such as ketamine and MDMA. This subreddit is dedicated to the discussion of therapeutic and recreational usage of dextromethorphan. I've never tried a dissociative besides nitrous before and haven't tripped in quite some time since I've had some bad problems with depression lately and some anxiety too. Your following the logic that if it make you feel better than it's an antidepressant but If that was the case than meth/heroin/cocaine are antidepressants as well. Dxm is active ingredient found in cough syrup. A single dose can relieve depression during the experience and maybe even for a few days during the afterglow. A study done where they tricked people who were dosed with dxm into thinking they were given psilocibin. Nmda antagonism, snri, sigma agonism, etc. I was even on an SSRI at the time, and my depression symptoms weren't much better than before I started doing either. I realize it's not well studied. I took advantage of the change in my mood and got a new job and visited some internet If DXM works for you and no one will end up convincing you to not use it as a treatment for depression, then just try and stay away from large doses of Acetaminophen which is a dangerous combination to the liver depending on the amount of dxm you are taking with it. [6] In 2022, the US Food and Drug Administration (FDA) approved the combination This post was automatically marked as "high risk" because it appears to referencing a compound found in the high risk wiki OR the title may include phrases often associated with risky posts. I abused dxm and continue to use dxm occasionally. Or check it out in the app stores     TOPICS Welcome to r/DXM - a community for discussion of the powerful dissociative cough suppressant - Dextromethorphan! is it hbr or freebase i always get the post trip depression on freebase, maybe try hbr Dextromethorphan (abgek. Happy Valentine's day. Get the Reddit app Scan this QR code to download the app now. The bupropion increases the effect of DXM a lot so I only take 10-20mg and it gives me a major mood/perception boost without any Do you think DXM improves things like mood and reduces anxiety in you? I’m curious if DXM could do similar things as ketamine for depression. doi: 10. Dxm psilocibin or placebo. I created a whole reddit just to comment and confirm withdrawal is real for dxm , while But replacing the friends you don't have, or the feelings you can't reach, with DXM (or anything except the real thing, really), is not what you want to do, and you know it. I eventually stopped, no particular reason, just noticed that my depression and anxiety was just sorta gone. The report from Tabuteau et al. I am kind of excited to see tests done in a controlled environment so they can find out if it has any psychiatric use or not. In general, exposures that fathers or sperm donors have are r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Tell them Devin sent you Feel free to goof as Age 20 with long lasting depression with a little anxiety but most depression, anergic, last of motivation, hypersomnia with a delayed sleep phase. Furthermore, interaction with DXM and an SSRI is potentially fatal, and these are risks I have taken seriously. It’s been a game changer, for both depression and anxiety. I haven’t had enough experience with dxm to compare it to a dxm high but it feels sorta like I felt that night camping. If it doesn't work for you, look into 60 mg Dextromethorphan (DXM) [as 30 mg q12hr] {EXPERIMENTAL!}- Tertiary antidepressant. So, i’m unsure as to which may be more effective and if dxm may cause impairment in memory especially since I have issues with memory already so I don’t want to exacerbate it. My energy envelope got better. Or check it out in the app stores Welcome to r/DXM - a community for discussion of the powerful dissociative cough suppressant - Dextromethorphan! Members Online • cummm_on_my_tongue. I’m on it for depression and it’s helped with that. anhedonia, reward processing, general cognitive systems) and/or whether it is able to significantly improve More serious dextromethorphan side effects include serotonin syndrome. My experience the other night with a bottle of Delsym kinda mindfucked me though, in a good way. Heute weiß man, dass die Substanz ein potentes Psychotropikum ist, das auf zahlreiche Hirnfunktionen Einfluss nimmt. In its pure form, dextromethorphan occurs as a white powder. Guide to DXM in Non-Prescription Drugs. FWIW, dextromethorphan DOES NOT "clear up mucus. , all contribute to the antidepressant effects but in turn can cause mania. 120mg/day if i remember correctly. I can't think of anything better to take when I want to clear my mind of bad thoughts and be constructive. As someone who once abused DXM on a regular basis, I don't think there's much to find here. it can help treat it temporarily but it is not a safe or sustainable way to manage your depression. DXM HBR: The most common form of DXM, often found in CVS syrups and most of the better syrups that are accessible to most people. I do have akathisia but that’s well-controlled by another medication. I did not know this until recently, I've been on Wellbutrin, AND Mirtazapine which will also potentiate DXM from what i've heard. Or check it out in the app stores   r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. " But one drug that helps thin mucus is guaifenesin, sold as Mucinex. Have you looked into D-ribose for chronic fatigue? Welcome to the #1 subreddit for The Sims franchise and community! Be sure to read the rules before posting or commenting, utilize the search feature, and check the wiki for Efficacy of dextromethorphan for the treatment of depression: A systematic review of preclinical and clinical trials. Then when I noticed the depression and anxiety was coming back, would do it again. I use the DXM w/Bupropion occasionally. High doses of DXM (dextromethorphan) and psilocybin, substances known for their hallucinogenic effects, can lead to significant psychological benefits when administered in a controlled, supportive setting, finds a new double-blind Thinking about trying the "AXS-05" combo of DXM and Wellbutrin (mainly for depression) - Has anyone tried it? Antidepressants A few years ago there was a lot of hype about AXS-05 which is just a "new" trial drug that is simply a combo of 45mg DXM (Dextromethorphan - ingredient in cough syrup) and 100mg of Wellbutrin twice a day. [3] DXM is also used recreationally. I’ve been doing exactly that, 300 mg XL bupropion in the morning and 45 DXM in the morning with the Bupropion, and then 45 DXM in the evening. I have had experience with this drug in the past, and have spent hours upon hours giving myself Get the Reddit app Scan this QR code to download the app now. For healthcare professionals. Zyban. DXM You don’t need script for DXM you can buy over the counter. Anyway dextromethorphan (DXM) is an ingredient in many cough syrups, and is sometimes used recreationally, which is OTC. It's called AXS-05. Or check it out in the app stores   Dextromethorphan as a daily med? benefits, etc). Personally, the first thought is a trap that convinced me to use dxm until I was "fixed" The second thought showed me that DXM "taught me" how to fight depression, and that it is up to me to force myself to maintain/fake the attitude that I have during a DXM experience. Especially with the word "literally" so close by. Welcome to r/DXM - a community for discussion of the powerful dissociative cough suppressant r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Initial research suggests that it can be a safe and effective treatment for people living with Dextromethorphan, sold under the brand name Robitussin among others, is a cough suppressant used in many cough and cold medicines. ADMIN MOD therapeutic depression doses? Question considering dxm as an offlabel depression It's not debilitating but chronic sore joints, fatigue depression anxiety and Dxm takes away the pain fatigue, and depression, but I'll crash at times like I could sleep all day long. 1898588 PMID: 33682569 > Crossref Medline Google Scholar; National Institute on Drug Abuse. I've got robotabs coming in the mail, and it just crossed my mind to check if they would interact with each other. It'll work better and cause less side effects. It's perfect for depression. These products may contain the same I ended up discontinuing it after my depression was resolved (this took under 2 months for pretty severe depression) because the feeling just made me feel uncomfortable in my body. Dollar to every nickel says that the folks spreading negativity in here aren't even half as happy and self-fulfilled as OP here. I’ve also managed to lose weight while taking it. Prozac has a very long half-life and it's not recommended to mix with Auvelity. Items are placed in the high risk wiki when they are on the market and either, 1. Access drug & treatment information, identify pills, check interactions and set up personal medication records. In order for DXM to be recreational it has to undergo metabiolism under CYP2D6 enzyme (as far as I remember, could be different one). 1080/14728214. Recently tried dxm for the first time. This demonstrates that the antidepressant-like effects of dextromethorphan do not require conversion to the metabolite dextrorphan, and reveals dextromethorphan itself has antidepressant efficacy. Discussion afterglow is great but sometimes when im feeling like a Many DXM-containing products (such as Coricidin Cough and Cold) also contain other active ingredients which can be dangerous or fatal in high doses. If you take wellbutrin I would not advise taking dxm unless you want to be out of commission for days (at least). I do not encourage anyone to use DXM beyond the recommended dosages but felt my experience should be shared. Gunakan sendok atau gelas takar dalam kemasan agar dosisnya akurat. Der Wirkstoff wurde als zentral (im Gehirn) wirksames Antitussivum (Hustenblocker) entwickelt. In the world of DXM, the main things you can do are either lengthen the trip in some way, by slowing the metabolization into inactive compounds (3-Methoxymorphinan [3MM]/ 3-hydroxymorphinan [3HM]) or decrease the speed at which DXM is metabolized into DXO (Dextrorphan), which results in a higher concentration of DXM in the body, which has the And than proceeded to pop 1 or 2 more 15mg dxm pills. Prompted by the recent article about an NMDA antagonist relieving suicidal depression in bipolars, I decided to guinea pig a chemical similar to ketamine: dextrorphan. Priority questions are whether DXM/bupropion is uniquely effective across discrete 76K subscribers in the dxm community. I stopped when I started ketamine therapy for depression because they work on the same receptors, but now that I'm done with that, I'll probably resume. it has a reputation for its abuse potential in young adults who intentionally get high on cough medicine (should be noted that some cough medicines have added ingredients like acetaminophen that make them dangerous to take at high levels). Dextromethorphan misuse is also possible, and this can lead to overdose. Sementara dextromethorphan sirop dalam kemasan saset bisa dikonsumsi langsung. Or check it out in the app stores   There's a new medication for depression up to stage 3 trials with these two drugs. Well I sort of read about it a few years ago, not for CFS but rather a few years ago a "new" drug combo made to combat treatment-resistant depression, as well as Alzheimer’s, known as AXS-05 (can google it) which is simply a combination of Wellbutrin (Bupropion) and DXM (Dextromethorphan). I got the idea from the ketamine depression therapy studies that were going on at the time and I was like "hey why not try dxm" DXM in theory might help depression in a similar way that ketamine can, but DXM is a sledgehammer, and will not help if taken often (binging or abuse). Since dxm is also an nmda antagonist - I was told it would work to help extend benefits of infusions. DXM in high doses is under studied and, hence, there lies unknowns and risks. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Dextromethorphan is an over-the-counter (OTC) drug that helps relieve a dry cough from a short-term cause. Mostly to Get the Reddit app Scan this QR code to download the app now. I can take dxm , even a micro dose, and be fine for half a year without it if not more. I am not suggesting we stop our psychiatric meds and psychotherapy for DXM though, I‘m just curious if regular users can notice an improvement in mood and a reduction in general anxiety after DXM use. I’m glad dxm has helped you so much but just remember that dxm can lead to addiction. While I have no doubt that what happened to you did in fact happen, and that it's a good thing for you, I would keep in mind that for those who struggle with severe, crippling depression DXM may be one of the worst things they can get themselves into. General adverse events. Miracle well but, bupropion alone did wonders so. If you wanna mix it Dextromethorphan has only recently been approved for the treatment of depression. DXM is not a cure to depression. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. 2021. Antidepressant effect of NMDA antagonism is seen at higher doses; it's simply tripping and you can't do that too regularly. If I understand this right Bupropion (Wellbutrin) inhibits CYP2D6 therefore potentiating DXM. This post was automatically marked as "NSFW" because it appears to referencing a compound found in the high risk wiki OR the title may include phrases often associated with risky posts. 10. Crazy mood swings, uncontrollable shaking, depression, insane urge to do DXM again. (2017). So if you decide to try anyways I Dextromethorphan received FDA approval in 1958 for its use as a cough suppressant. I might be starting LDN soon, waiting on approval from the provider, so I'll probably wait for that to stablinze before continuing dextromethorphan. Check nonprescription cough and cold product labels carefully before using 2 or more products at the same time. It’s hard to describe what the rest of the high is like but it is NOT the same as a normal strong weed high. Alot. Here's what I tried and what happened. I was on Prozac 20mg at that time in January and tapered down within 2 weeks. I’ve gone back just bupropion 150xl. Here we discuss best practices, harm-reduction, chemical and pharmacological properties, and addiction support for the OTC cough suppressant known as dextromethorphan. So you get DXM's potential MOA (SERT/NET blocker, sigma1 agonist, NMDA antagonist, some others) combined with whatever bupropion does for you, if any (DAT, etc). I found some studies supporting the notion that DXM would have the same antidepressant effects as ketamine. He was saying respiratory depression because you're mixing a benzo and dxm but the dxm dose isn't that high (and you have tolerance) and you have a benzo addiction so that small benzo dose isn't actually making respiratory depression any more likely. I'm gonna be honest for the first few weeks it felt like i was taking a low dose of molly everyday. Or check it out in the app stores Auvelity is an expensive version of Wellbutrin/bupropion combined with dextromethorphan (dxm). For me DXM helps depression because the DXM experience is so dysphoric and unpleasant, that I used to do dxm a lot and i would test my limits, i liked to stay up through as much as i could and enjoy the high. DXM is addictive, especially to people suffering from depression. DXM is often abused in high doses by adolescents to generate euphoria and visual and auditory hallucinations. It also seems to have the potential to help with depression (works similarly to ketamine and is found in auvelity, a new-ish fast-acting antidepressant). As well as substance dependency issues. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. But that's not viable for everyone. If a male takes dextromethorphan, could it affect fertility (ability to get partner pregnant) or increase the chance of birth defects? Studies have not been done to see if dextromethorphan could affect male fertility or increase the chance of birth defects above the background risk. This is just a thread to summarize your experiences and opinions on using DXM for depression, Posted by u/sm1ng - 1 vote and 18 comments Well it is misleading to use the words "depression" and "cure" in such close proximity. I’m not entirely out of the woods but I’m better than I was. DXM is unscheduled and the way they made the combination, users cannot abuse it whatsoever (since most of the recreational effects are from DXO The experience below is my subjective experience. Then I crashed for some reason. Robitussin Information. Dextrorphan is a metabolite of dextromethorphan HBr, which can be found in most over the counter cough syrups. Dextromethorphan (Delsym) is available as an extended-release (ER) cough syrup that's taken by mouth, typically every 12 hours. I've read that DXM can be a highly effective (albeit addictive and dangerous-if-overdone) treatment for depression. com Dextromethorphan hydrobromid là thuốc giảm ho tác dụng trên trung tâm ho ở hành não. in this issue of the Journal indicates that the combination of 90 mg of dextromethorphan and 210 mg of bupropion (AXS-05) is significantly more effective than bupropion alone in patients with Dextromethorphan (DXM) is an over-the-counter (OTC) cough suppressant commonly found in cold medications. Untuk dextromethorphan serbuk dalam kemasan saset, tuang serbuk obat dalam air putih sesuai takaran pada petunjuk penggunaan. Internet Culture (Viral) Amazing And of course, I would caution you about your own tolerance - low dose DXM is a good thing for depression (in my experience), but it does not last forever if you're doing it every day. morphine, heroin). Adverse effects have included gastrointestinal disturbances such as stomach upset and diarrhea. That’s really the only downside, and it’s not bad enough to warrant stopping the medication. So shy she could barely speak to me She's now up and out of bed each morning, working part time and enjoying it, socializing, and smiling. well dextromethorphan is a medicine for cough and nowadays it's approved for the treatment of depression. It’s called robocough on Amazon. bupropion is already approved for depression, 2. This is no recommendation. And at high doses dxm can also cause trippy k type effects. I tried 60mg a day and it brought me out of depression for a couple weeks. Welcome to r/DXM - a community for discussion of the powerful dissociative cough suppressant While dextromethorphan-bupropion is a promising treatment for depression, there are several issues that may limit its clinical utility. Posted by u/SubatomicParticlesNo - 2 votes and 2 comments Get the Reddit app Scan this QR code to download the app now. Expert opinion . It is one of the most common compounds found in most over-the-counter antitussives for the past 50 years. DXM products to persons under the age of 18. I fear because DXM is serotonergic some sort of tolerance could develop. I ordered pure dxm without all the other junk in it. Still taking SSRI, which I dont think works anyway. deobgb nbxoo xkgxb rknw imnh tyrl hfciul pydmbl pxhk gtadu qosg ebx njcg ysnix axthz